To coordinate, support, monitor, and evaluate the implementation of the African Union One Health Strategy for Zoonotic Disease Prevention and Control across the Member States, the African Union Interagency Group on One Health has been established. The Interagency was established during a meeting on One Health that took place from 13-14 June 2022 at AU-IBAR in Nairobi, Kenya. The Interagency comprises several AU offices that have been mandated to deal with various aspects of human/ animal health interventions, namely: The Africa Centre for Disease Control and Prevention (Africa CDC); The African Union InterAfrican Bureau for Animal Resources (AU-IBAR); The Scientific, Technical and Research Commission (STRC); The Department of Agriculture, Rural Development and Blue Economy (DARBE); The Department of Health, Humanitarian Affairs, and Social Development (HHS); the InterAfrican Phytosanitary Council (AU-IAPSC); and the Citizens and Diaspora Organizations (CIDO).

The interagency will specifically be tasked with achieving several objectives; namely: the  development of the AU One Health Strategy for zoonotic diseases; the development of  a consensual road map for the implementation of One Health Strategy for zoonotic diseases in Africa; undertake an inventory of Zoonotic Disease Prevention and Control related activities; coordinate, monitor, and evaluate implementation activities of the AU One Health Strategy Zoonotic Diseases;  compile an inventory of Zoonotic Disease Prevention and Control associated activities being undertaken by the different AU institutions, document the roles of the institutions in the control and prevention of Zoonotic diseases, and  to coordinate implement, monitoring and evaluation of the AU One Health Strategy Zoonotic Diseases activities.