Since the cholera outbreak was declared by the Ministry of Health on 10 September, tens of thousands of suspected acute watery diarrhoea (AWD) cases have been reported in all governorates. Aleppo governorate in northwest Syria has been among the most impacted areas.

UNICEF has supported the efforts of the Ministry of Health (MoH) to curb the spread of the disease through the provision of Oral Cholera Vaccines that arrived in the country in late November 2022. A two-week immunization campaign, supported by UNICEF and WHO, started on 4 December. It aimed to reach vulnerable people in the highly affected governorates: Aleppo, Ar-Raqqa Al-Hassakeh, and Deir ez-Zor.